Everything you need to know about CBD for Depression

CBD for Depression

In this article, we discuss everything you need to know about CBD for depression and go in-depth into the existing evidence that supports the use of cannabidiol as a legitimate treatment for depression.

If you feel you or someone you know is in crisis, please call the National Suicide Prevention Lifeline. It is a free, 24-hour hotline, at 1.800.273.TALK (8255). Your call will be connected to the crisis center nearest to you. If you are in an emergency, call 911 or go to your nearest emergency room.

Anyone that has spent days or weeks hiding under the covers, drapes drawn and wallowing in a prolonged state of worthlessness knows that depression is one of the most difficult and traumatic psychological ailments a person can suffer from.

The World Health Organization estimates that more than 300 million people worldwide, and 16.2 million Americans, suffer from some form of depression.

Wellness website Healthline defines depression as:

“Depression is classified as a mood disorder. It may be described as feelings of sadness, loss, or anger that interfere with a person’s everyday activities.

People experience depression in different ways. It may interfere with your daily work, resulting in lost time and lower productivity. It also can influence relationships and some chronic health conditions.”

There are number of acute forms that depression can take, from Seasonal Affective Disorder to chronic and manic depression, and typical symptoms include:

  • Loss of interest in your activities
  • Weight loss or gain
  • Feeling worthless
  • Feeling restless and/or bothered, or sluggish mentally
  • Insomnia, or sleeping during the day
  • Trouble concentrating
  • Suicidal thoughts

If you are suffering from any of these symptoms and believe that you may be suffering from clinical depression, please visit your doctor and seek professional diagnosis before attempting to treat this problem.

Statistics about Depression

  • Major depressive disorder affects approximately 16.2 million Americans (World Health Organization)

  • The median age for depression onset is 32. (U.S. Census Bureau Population Estimates by Demographic Characteristics)

  • People with depression are 4x as likely to have a heart attack than those without a history of the illness. (National Institute of Mental Health)

  • About 6 million people are affected by depression later in life, but only 1 in 10 receive treatment. (Brown University Long Term Care Quarterly)

  • Women experience depression at twice the rate of men (Journal of the American Medical Association)

  • Depression costs U.S. businesses around $70 billion in medical expenditures, lost productivity and other costs every year. Depression accounts for close to $12 billion in lost workdays each year (The Wall Street Journal)

  • 10.3 million U.S. adults experienced an episode that resulted in severe impairment in the past year (SAMHSA)

  • Nearly 50 percent of all people diagnosed with depression are also diagnosed with an anxiety disorder (Anxiety and Depression Association of America)

  • 20 percent of millennials report depression in the workplace (Depression and Work: The Impact of Depression on Different Generations of Employees)

How Do People Treat Depression

Prescription Drugs

Selective serotonin reuptake inhibitors (SSRIs) are the most widely used treatment for anxiety and depression.

Some of the most common and widely used SSRIs include fluoxetine (Prozac), citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva), sertraline (Zoloft) and vilazodone (Viibryd). The most famous SSRI is Prozac, though a recent study published in The Lancent found it to be among the least effective but best tolerated.

But prescription drugs aren’t for everyone.

As we’re sure you know, America is in the throes of a widespread prescription drug epidemic at the moment. While opiates such as oxycontin and fentanyl get the bulk of the headlines, drugs like Prozac, Lexapro, Xanax, and Adderall can all lead to dependency and addiction.


Another means of combating depression is looking carefully at your lifestyle and identifying areas in which you can treat your body and soul with more care.

A good diet is often cited as a necessary attribute to feeling balanced and content, with fatty acids, amino acids and complex carbohydrates all working hard to fend off depression.

Alcohol has been shown time and again to be a significant contributor to depression, and if you are suffering from an episode you should avoid searching for solace in the bottom of a bottle. It inevitably leads you deeper.

You can also look to improve sleep, stay hydrated, meditate, and generally live like the radiant healthy human you always hoped you would become.

Significant Promise in CBD for Depression

CBD Products
KushyCBD Award-Winning Products

CBD has found huge support among those suffering from and living with depression.

“I’m using CBD to replace anti-anxiety medication and to help with depression. The last month of my life has been amazing thanks to your product. I have the ability to go outside and actually enjoy life without having panic attacks.”



“I suffer from depression almost every winter, and until recently had been prescribed Zoloft to keep me leveled out. I really didn’t like the side effects though. I did some research on alternative treatments and found KushyCBD. It made the long winters tolerable, and improved my life tremendously”


To read more CBD success stories, visit our testimonials page.

The limited studies into CBD’s potential to treat depression have been promising. A study published in Molecular Neurobiology in 2018 set out to explore CBD’s application as a fast-acting treatment for depression by administering it to rats and using a well-established antidepressant methodology called the forced swim test.

“The conclusion was that the effects of treatment with cannabidiol were fast-acting and sustained, persisting for up to seven days after a single dose was administered to animals belonging to different models of depression (including a stress model and a genetic susceptibility model),” writes the paper’s authors.

“Seven days after treatment, the researchers observed a rise in the number of synaptic proteins in the prefrontal cortex, which is closely linked to depression in humans. In light of this finding, we believe cannabidiol rapidly triggers neuroplastic mechanisms that help repair the neuronal circuitry that gets damaged in depression,” Prof. Joca, one of the paper’s authors, wrote.

“If studies in humans also find cannabidiol to be beneficial in treating depression, given that cannabidiol is already used in humans to treat other diseases or disorders, “they could result in an important advance in the treatment of depression, potentially helping patients who suffer for weeks, often with a risk of suicide, until the treatment starts working.”

To read the full report, click here.

Further Reading

  • https://www.depressionalliance.org/cbd-oil/
  • https://www.ncbi.nlm.nih.gov/pubmed/21916860
  • https://www.ncbi.nlm.nih.gov/pubmed/26711860
  • https://www.ncbi.nlm.nih.gov/pubmed/20332000
  • https://keytocannabis.com/blogs/cannabis/cbd-for-depression
  • https://cbd-international.net/will-cannabis-oil-help-depression/
  • https://depressionhealth.net/articles/treating-depression-with-cbd-oil.html
  • https://www.drugtargetreview.com/news/34844/cbd-shows-sustained-effects-against-depression/


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